Grid has been around for a while now, together with flex it’s the way to go to start building layouts. But like everything it requires practice to get the nuances down and learn about the pitfalls. You won’t experience many cross browser issues these days with either of them. And in terms of accessibility you mostly need to consider that visual order does not necessarily match tab order. Especially for grid where you can arbitrarily place elements in the grid.

An older resource for learning grid would be https://youtube.com/playlist?list=PLu8EoSxDXHP5CIFvt9-ze3Ing.... 6 years old but grid itself has gone mostly unchanged. https://css-tricks.com/snippets/css/complete-guide-grid/ https://css-tricks.com/snippets/css/a-guide-to-flexbox/

https://flexboxfroggy.com/ Is a good way to introduce yourself with the concepts of flexbox.