You (and I to a certain extent) need to be more specific. You've provided a list of screen readers. What I was really trying to say was "when someone argues that a particular markup or technique has benefits, then they need to demonstrate a real user with a real need who will benefit using shipping technology".
So we would need to pick a particular point of contention and then we can argue the toss.
PS If you read the Mark Pilgrim IRC logs he caricatured the response he often found when criticising any aspect of accessibility best-practise as "OMG!!! YOU HATE BLIND PEOPLE!!!". It's an effective way of shutting down debate and doesn't help anyone.
So we would need to pick a particular point of contention and then we can argue the toss.