> One missing ingredient is a probabilistic model of the thing you're imaging
Ooh, this (making the prior for the true image signal more informative by incorporating knowledge of the structure of the signal) is clever.
Here, when you say model, you mean a description that is based on the (bio)physics of your sample? (E.g., knowing that objects being imaged obey diffusion equations informs your maximum likelihood estimation of the true signal?)
> Secret because I have a dream for a crazy startup based on this idea which I don't have the means to do now. Although I generally hate being secretive about, like, knowledge and for sure the value creation happens during execution - but just humor me this time, ok?
Of course; such is the right (and joy) of an innovator to define how one's own idea is disseminated/actualized! (~:
It is intriguing that you feel your idea has the character of best being pursued via a startup (addressing some crucial unmet commercial need), rather than via the academic model (e.g. transformative Nature publication) more commonly used for improved microscopy techniques.
Best of luck in this pursuit; I look forward to seeing your startup's innovations someday soon!
> You need to understand the whole picture, how it works on each level, and how the levels fit together - then you can run thought experiments. A good generative model of the world.
This idea of developing a "good generative model of the world" is a beautiful aspiration for all of us to have. Thanks for your insights!
> One missing ingredient is a probabilistic model of the thing you're imaging
Ooh, this (making the prior for the true image signal more informative by incorporating knowledge of the structure of the signal) is clever. Here, when you say model, you mean a description that is based on the (bio)physics of your sample? (E.g., knowing that objects being imaged obey diffusion equations informs your maximum likelihood estimation of the true signal?)
> Secret because I have a dream for a crazy startup based on this idea which I don't have the means to do now. Although I generally hate being secretive about, like, knowledge and for sure the value creation happens during execution - but just humor me this time, ok?
Of course; such is the right (and joy) of an innovator to define how one's own idea is disseminated/actualized! (~: It is intriguing that you feel your idea has the character of best being pursued via a startup (addressing some crucial unmet commercial need), rather than via the academic model (e.g. transformative Nature publication) more commonly used for improved microscopy techniques. Best of luck in this pursuit; I look forward to seeing your startup's innovations someday soon!
> You need to understand the whole picture, how it works on each level, and how the levels fit together - then you can run thought experiments. A good generative model of the world.
This idea of developing a "good generative model of the world" is a beautiful aspiration for all of us to have. Thanks for your insights!