Meanwhile the LP crowd was flipping sides like it was Ultima VIII (slight exaggeration). Why would it be critical for a new format to do away with multi-disc releases if the customer base has already grown accustomed to them?
For classical music it's a problem because the long track lengths mean that you'll have to flip the record over in the middle of a piece. This was enough of an annoyance that one French label in the 70s created special records just for classical music with extra tightly packed grooves that could hold close to an hour on each side (https://www.discogs.com/label/184887-Trimicron). The downside of this is that the maximum recording volume is significantly reduced so there's a lot more background noise than on a normal record.
Me neither, but I got something similar from the abstract that I was about to ask, so adding it here: "Following infection, vaccinated mice mounted rapid pathogen-specific T cell and antibody responses and formed ectopic lymphoid structures in the lung."
That latter term (ectopic lymphoid structure) comes up in connection with persistent inflammation where the immune system sets up camp near the problem point. Is this good or bad? Do these go away once the infection clears up?
These are pretty common, physiologic structures associated with infections. They can be just a handful of cells on a slide or be quite large, and I don't know what they found in these infections. I didn't read the original paper. The ectopic lymphoid structures go away after the infection resolves. It seems that the immune system has ways to set up mini lymph node architecture right by the site of infections, which is very sensible. The same process is going on in a more organized way in the draining lymph node in parallel. Research into these was really hot in the 2010s, but people don't seem to be as into them anymore (but my research has also transitioned to innate immunity from adaptive, so it's likely that I'm no longer in that universe).
In general, it doesn't surprise me that when you prime the innate immune system, the adaptive immune system works well. The problem is that pathogens have an incredible suite of tools ready to evade these mechanisms. The doses of the pathogens are typically insanely high too, which I do not think model natural infections well. Anyways, this is intriguing, so I'll take a look at the original paper one of these days. Vaccine research generally is so boring. It's like, we vaccinated, and it worked, or didn't, no mechanism.
I always thought it's an optimization problem: the headstock is pulled by the strings towards the guitar's body, and whenever you get one string in tune, the change in (the distribution of) force changes the tuning of all other strings as well. So ideally they should be moved into an acceptable configuration collectively. People with six hands should be able to do it.
If you've been storing it with strings loose and are bringing it into tune you definitely gradually tighten all the strings rather than just doing it in sequence, for that reason
Use an agent to summarize and generate reproducers for each report, another to select issues to be fixed in the next iteration, a third one to implement changes, a fourth for code review...
"Someday - and that day may never come" - they will be asking for something. Now you are on talking terms and it will be harder to refuse the ask, compared to the request of a complete stranger.
> this is a compatibility character provided for roundtrip compatibility with legacy encodings. […] The Unicode standard explicitly discourages the use of this character
I'm sort of buying and not buying this interpretation. Celsius is discussed under section "Unit symbols" in the PDF (page 8-9 of the linked Chapter 22), where the quoted "it is better" sentence appears...
...then immediately afterwards a new section named "Compatibility" starts where the use of code points that are composites of several letters, e.g. ℡ and ℻ are indeed discouraged, suggesting they be spelled out in full as TEL and FAX instead.
Do you feel ℃ falls into a continuation/overlap between these two sections?
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