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On Mac there is Hype. The earlier versions were pretty good, but I haven't used the latest. https://tumult.com/hype/


The problem with the 12c Platinum, is that it was a "ground-up" rewrite, and is actually slower than the early 80s 12c.


It’s slower? Any proof of that? I believe it is slower than the most recent revision of the 12C, but it’s certainly faster than the original 12C. The Platinum has many more registers which I find outweighs the improved speed of the current 12C. The stack push behavior of the Platinum also helps make programs a little shorter from my experience.


Three words "Lake Effect snow"...


That’s only really on the west side of the state. If you’re an engineer you probably want to be in SE Michigan which doesn’t really have lake effect snow.


If you work remotely you can live all over Michigan. Not just SE Michigan. It depends what you're in to. I've know teleworkers who have been in the UP, the thumb, and every place in between. Depends on what you're interested in outside of coding hours.


Also I killed 2 via running Jetbeans. (Client requirement not my choice...)


Wow, this is something that I have been looking for ~a year!

Great job, can't wait to dust that project idea off the shelf!


Awesome! If you need any help with your project I am happy to help :)


Your looking at it wrong.

A doctor's appointment schedule is crazy busy, with "LONG" appointments being under 20min per patient. Imagine a scenario where a doctor is able to spend time with the patient/their medical history etc.

I spend a lot of time going to doctors appointments these days, and a large number of the doctors that I see, now have an assistant/transcriptionist in the room to manage the EMR/charting app, because that enables them to focus on the patient.


I've never understood this argument. Right now we have decided implicitly as a society we're fine with the current level of care. If we can provide that same level of care cheaper, what makes you think health care providers will decide to pass those savings onto patients in the form of more care for the same price?


I would disagree with this statement. Every year, expectations rise, and it is becoming increasingly difficult to meet these expectations. Furthermore, I think expectations are tempered by the knowledge that staff are over worked and time is limited. It is infeasible to practice medicine the way it us taught in medical school in practice due to time constraints. And like everything else, the work tends to fit the time available.


I hope very much you're right, and that as medicine gets cheaper we get more of it.


Would the doctors take fewer appointments per day and make less money? Or do doctors get paid by the hour?


In Germany they are paid a fixed amount for each patient in a quarter by public insurance.

So they want to minimize the time they spend on each and prefer to give a second appointment months later


Guess I'm not moving to Germany then!


That's definitely one way to look at it. And I hope that's what happens. But is it really wrong to speculate that that isn't going to happen? I think it would be naive to not speculate how we would handle such a situation. Contingency plans are important.


Alibaba...

A few years back, I was prescribed a anti cancer, prescription drug that costs $4k per box. (5mg per day, 28day day supply).

I went on Ali, and ordered 5lbs of the drug for $100 usd including shipping.


Honest question, how do you know you're actually getting the correct drug and that it isn't contaminated or cut with something else?


You could send it to a chemist and ask them to do an NMR and have a pretty good idea (provided it’s just one molecule)


You can test it yourself, but many times the same manufacturer in the USA is the same abroad.

I would say India for Drugs is not a bad idea - if you're worried it's "from" China.


> I would say India for Drugs is not a bad idea - if you're worried it's "from" China.

Then again:

https://peterattiamd.com/katherineeban/

> The story of Ranbaxy: An Indian drug company whose business model was fraud and deceit [40:45]


Good link. On his podcast, Peter has also talked about generics vs. name brand differences. He had a chemist on who started a pharmacy selling generics where some statistically significant amount of each batch of drugs is tested for chemical verification.


"You can test it yourself" : If you die, just make sure to leave a bad review on Alibaba. Do your bit to prevent survivor bias.


I meant by a reagent test. Not consumption.


I have not the remotest idea how I would test a cancer drug for myself to see if it was pure. I suppose I could hire a chemical laboratory, if I could figure out what kind of one would do that kind of work...


> I have not the remotest idea how I would test a cancer drug for myself

As someone with only a high school level of chemistry training I would check the melting temperature.

Although seriously get it professionally tested. The delta between USA prices and India/China prices is so high a lab test will barely change the margins.


The first thing to do would be look up the Scientific Discussion or Monograph as filed with the FDA for the brand name product. With the details obtained from there, you'd know what to test for.

The first steps would be assay and impurity tests for the active pharmaceutical ingredients (API). If you bought tablets you'd probably want to do dissolution as well.

If everything looked fine after that, I'd still be concerned about uniformity. If you just performed dissolution on half a dozen tablets, how do you know all the tablets are the same from the whole supply?

Next question is then stability. What happens to the API over an extended time period? Does it deteriorate due to climate or poor storage conditions?

The main issue is quality control. Even an approved generic has to file with the FDA (or equivalent of wherever you are) concerning processes, batch sizes, critical quality attributes etc.


> if I could figure out what kind of one would do that kind of work

Open up the phone book. I'm sure you can find one within a day.

Chemists like money. Especially when it's not even a controlled drug.


Probably the best way is to use a mass-spectrometer.


Hopefully they don't send you an inactive enantiomer!

Or an insoluble polymorph.

Realistically, a lot of cancer drugs are injectables, ramping up the risk of something going awry when you inject the powder you will have to handle.


I'm guessing the people who can afford a mass spectrometer can already afford the drug (or at least better insurance)


Heh, well if the drug is $4k a month and you can get the equivalent 5 year supply for $100 that leaves quite a bit of money left over for testing.

There are lab services that will run samples through a mass spec and report the results.


AFAIK Drugs are not available anymore on Alibaba.

You should not buy such important drugs from a dubious source.

Drugs from an official Chinese Pharmacy are probably very safe. If someone sells sugar instead of antibiotics be assured that he might face the death penalty.

Most raw materials are produces in China anyway, even if the medication is obtained from a western company.

BTW, was the cancer medication for injection?


Did you need to handle the customs paperwork? I find it hard to believe the customs would just ignore a bunch of strange powder coming through the mail...

And even if they did believe you it was not cocaine, I would still assume they would not be happy about someone importing a prescription drug.


> ordered 5lbs of the drug for $100 usd including shipping.

Nothing like the sensation of dying with placebos knowing that you saved $4k dollars and you are smarter than the other guys. Can be done even cheaper: you could have obtained lots of carrot juice for $50 also. Did not worked for Jobs but maybe in your case could be different, why risk not trying?.

Seriously, don't do this. Even legit chemoterapy can dissolve you from inside and I'm not talking metaphorically. There are reported cases of unexpected and massive organ destruction. Chemoterapy is poison, can kill you faster than cancer if you have a secondary hidden condition.


Interesting. They now have a policy that prohibits the sale of medication. I wonder if there are other less scrupulous competitors of Alibaba...


I can still find stuff like amoxicilline, ketoconazole or paracetamol on Alibaba. Maybe the ban is only on some specific chemicals?


And what was the name of this drug?


I have a really rare cancer, and it didn't get detected until I hit stage IV and it started shattering my bones. Thankfully I lived 2 miles from a cancer research hospital that actually has a specialist in this type of organ cancer.

My current treatment regime is based on a research paper. My insurance initially denied me treatment based on "an expert in the field" and stupidly listed the doctors name. I looked her up and she was a podiatrist...

For the most part, my treatment is dialed in and mostly working. But I had a solid three months of fighting with the insurance company to get all of the medications, and I do the monthly phone calls to three different specialty pharmacies to get all of the various things that keep me able to walk.

Its a crazy hard problem because one of my medications is a "failed" cancer drug. Tens of millions of dollars worth of R&D, several clinical trials, and it turns out it doesn't work on most common cancers. (And even on cancers it does work on, its usually used as a Hail Mary play, at EOL because it might give someone a few more weeks, maybe). It costs roughly 40k a month, and I might be stuck on it for the rest of my days.


Anecdotes are great and all, but we still don't know if the textbook treatment would have worked better or not.

Certainly those that failed with the exotic treatment plans won't be around to complain about it.


No, I'm so sick of the local cancer centers rotating corps of musicians. Want me to get stabby? Keep playing your drum hippie...


Or if it's an "Art Installation"


They have had a very solid store business at one point selling electronic kits. (Pi's, Arduino, etc).

A few years ago the kits were even in every Barnes and Nobel ni the country at Christmas. (And sadly most of them were in the clearance bin in January...)


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