I've had a similar experience. After struggling with react and ember for a while, I ended up switching to using Vue, which IMHO, has a much simpler setup with Vue loader.
I'm also using Bootstrap 4a5 without issues on a small site that I initially upgraded from Bootstrap 3 mostly out of curiosity, and then pushed live when I didn't discover any major issues.
Since it's a "major rewrite of almost the entire project"[1], I can't recommend that new Bootstrap users invest any time in Bootstrap 3.